Ipamorelin (from Ipamorelin) – belongs to the group of peptide hormones, increases the secretion of growth hormone and mimics the action of ghrelin in the body. It does not cause significant changes in appetite.

Distinctive feature of Ipamorelin is the greater influence on stimulation of growth hormone (GH) secretion than other GHRP (growth hormone releasing hormones), as well as maintenance of natural growth hormone production with peaks in certain hours. Ipamorelin belongs to the latest generation of growth hormone stimulating hormones (GHRP).

The release of growth hormone is associated with both suppression of somatostatin (a hormone that inhibits GH secretion) and direct stimulation of growth hormone release from the anterior pituitary lobe, as in the case of GHRP-6.


Course and Doses

The maximum effective dosage in most studies on GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as 100 mcg or 1mcg/kg, which is administered 2-3 times daily, subcutaneously

This means that 100 mcg of the substance will load the pituitary receptors almost completely, but if you add another 100 mcg, the effect will only be more pronounced by 25-50% of the original dose. Further increasing the dose will result in even less of the anabolic and lipolytic effect achieved in bodybuilding.

Ipamorelin acts synergistically (multiplies the effect) when used in conjunction with the growth hormone stimulants GHRH: CJC-1295 or GRF(1-29). The combination not only allows for a better result, but also saves money.

Ipamorelin is also different in that being as effective as GHRP-6 in stimulating growth hormone production, even at higher doses (over 100 mcg) it practically does not stimulate prolactin and cortisol production. According to Yu Bombela, maximum results are achieved when combined with anabolic steroids.

Preparation and storage of the solution

The vial should be cooled to room temperature, then the necessary volume of water for injection (which should flow down the wall of the vial) should be injected and placed in a rotating motion (do not shake). The solution is quite stable. Shelf life in the refrigerator is 20-25 days without freezing.

Comparison with counterparts

GHRP-6 at a dose of 100 mcg also has practically no stimulation of prolactin and cortisol production, but can cause it at higher doses. It has the same ability to stimulate GH secretion as Ipamorelin.

GHRP-2 is slightly more effective than GHRP-6 for GH production, but at doses of 100 mcg and above, can measurably stimulate prolactin and cortisol production. Their levels would still be within the normal range, although at doses of 200 to 400 mcg of GHRP-2, the levels of cortisol and prolactin could be higher than normal.

Hexarelin is the most effective of all GHRPs in stimulating growth hormone production. However, it also has the highest potential for increasing cortisol and prolactin levels. Even at a dosage of 100 mcg, the cortisol and prolactin concentrations in the blood are rising considerably.

Based on all of the above, Ipamorelin is currently the best choice of all GHRPs in terms of safety, even at high dosages. This peptide does not increase the production of cortisol or prolactin, but it is very active in the production of GHRP.

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