GHRP-6 and Hexarelin, (HEX) – Growth hormone secretion stimulants, which is a peptide by nature. Hexarelin is a structural analog of GHRP-6, has the same effects, and is used in the same dosages, so they are often considered synonymous. These substances were developed to treat growth hormone deficiency.
GHRP-6 is similar to GHRP-2 in many ways, the main difference being that the latter is about 1.5 times more potent as a GH booster, but it also increases prolactin and cortisol concentrations. These peptides can be used together to achieve a synergistic effect. In the studies, the maximum concentrations of growth hormone in the blood were observed when GHRP-6 and GHRP-2 were administered together.
Effect on appetite. Lately controversial opinions on the effect of these ghrelin agonists on appetite have been spreading, especially after the publication of Iron World (Peptides part 1, by Dmitry Ustimenko), where they wrote: Ghrelin is the appetite hormone. It is stimulated by HCRP-6 and HCRP-2. Ghrelin release is influenced more by HCRP-6 than by HCRP-2.
First of all, this is a gross misapprehension, because they do not increase ghrelin production, but are its mimetics. However, both peptides cause a marked increase in appetite, which has been documented in various scientific papers. In addition, GHRP-2 has the additional effect of cortisol, which also increases hunger. GHRP-6 has a somewhat greater effect on appetite, according to reports of athletes. This effect usually wears off after 2 weeks of supplementation.
Hexarelin and GHRP-6 can be injected into the body in different ways: subcutaneously, internally, under the tongue, or transbuccally, but most often intramuscularly. The molecules of this substance are so small that they are able to pass through the vessels of the mouth and stomach before being destroyed by digestive enzymes. Nevertheless, optimal bioavailability is ensured only by injection routes of administration.
Use in Bodybuilding
Although it is a new drug, Hexarelin has already become a popular choice for athletes as a means of increasing endurance and muscle definition. GHRP-6 is available as several brands. Virtually all of the products come from China.
Action
The main action of GHRP-6 is to stimulate the secretion of growth hormone, so most of the effects are similar to those of growth hormone.
The effects of GHRP-6 are listed below:
- Increased strength performance
- Muscle growth
- Fat burning
- Strengthening of definition
- Increased appetite
- Rejuvenating effect (better skin and hair)
- Strengthening of the immune system
- Strengthen bones
- Protects the liver
- Anti-inflammatory effect
Research data
In studies when Hexarelin is injected subcutaneously, the concentration of growth hormone increases significantly within thirty minutes after injection. During the next four hours after the injection the concentration of growth hormone gradually decreases to the initial concentration.
Dosage and administration regimen
Tests have shown that the optimal single dose of GHRP-6 is 1 mcg per 1 kg body weight. If the dose is decreased, a weaker increase of growth hormone is observed, but the higher dose does not increase growth hormone secretion. For example, if the dose is increased from 100 to 200 mcg, the increase of growth hormone concentration will differ only by 25%, so 100 mcg is considered an optimal dose in bodybuilding. The drug is administered three times a day – after training, 15 minutes before meals and before going to bed.
It was also found that the body gradually adapts to the action of GHRP-6, respectively, the effectiveness of the drug decreases. Tolerance (desensitization) occurred in the studied people after 4-16 weeks of intake. For this reason, if you do not want to waste your finances, the duration of the course should not exceed 4-8 weeks, after which you should take a break for 1-2 weeks.
The problem of desensitization is also solved by combining with CJC-1295, this “combination is now recognized as the gold standard.”
Preparation and storage of the solution
The vial should be cooled to room temperature, then introduce the necessary volume of water for injection (which should flow down the wall of the vial) and stir with smooth rotating movements (do not shake) or let stand in the refrigerator. The solution is quite stable. Moreover, stability in this case does not depend on the type of solvent (bacteriostatic water or water for injection). Shelf life in the refrigerator is about 30-35 days.
Combination
The effectiveness of the GHRP-6 course can be greatly improved by combining it with other growth hormone stimulants or anabolic steroids.
- CJC-1295 or GRF(1-29) are the best choices for combination. They increase the effect of GHRP-6 by several times. This combination is now recognized as the gold standard in bodybuilding.
- GHRP-2 – according to some sources, the combination will more than double the effectiveness of the course, although the practical results remain questionable.
- Insulin – will increase course effectiveness by 30-40%
- Arginine – will increase effectiveness by 10-20%
- Glutamine
- GABA
Side Effects
During the studies no serious side effects of GHRP-6 were registered, on the contrary, the preparation increased the protective properties of the body. GHRP-6 is prescribed even in children. At higher doses (600 mcg/day or more), it can increase the concentration of prolactin and cortisol, but to a much smaller degree than GHRP-2. It causes a burning sensation at the injection sites – which subsides after 5-10 minutes.
